Antonio
Mastino
Email: 
antonio.mastino@unime.it
Allegati: 

ALTRE INFORMAZIONI

SSD: BIO/19
Profilo: Professori Ordinari

CURRICULUM

Curriculum

 
 
 
 
Prof. Antonio Mastino
 
CONTATTI:
Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali,
Università degli Studi di Messina,
Via F. Stagno d'Alcontres, 31
98166 - Messina – ITALY
tel. +39 3388658161
e-mail: antonio.mastino@unime.it
 
 
BREVE BIOGRAFIA
 
Il Professore Antonio Mastino ha conseguito la laurea in Scienze Biologiche e la Specializzazione in Microbiologia presso l'Università di Roma La Sapienza, a Roma. Ha poi prestato servizio come Ricercatore Universitario presso l'Università di Roma "Tor Vergata", a Roma. Successivamente, nel 1995, è stato nominato Professore Ordinario di Microbiologia Generale e trasferito all'Università di Messina, a Messina, dove ancora attualmente afferisce al Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali. Presso l'Università di Messina, il professor Mastino ha ricoperto per diversi anni l’incarico di Direttore dei Dipartimenti di Microbiologia, Genetica e Scienze Molecolari, prima, e successivamente di Scienze della Vita "M. Malpighi". Ha anche ricoperto l’incarico di delegato del Rettore per la gestione delle risorse della ricerca.
Il Prof. Mastino  ricopre anche attualmente, dal 2013, l’incarico di Presidente dell’ Area di Ricerca di Roma Tor Vergata del Consiglio Nazionale delle Ricerche (CNR), a Roma, ed ha precedentemente ricoperto l’incarico di Direttore dell’Istituto di Farmacologia Traslazionale, sempre del CNR.
 
ResponsabilitA’ di PROGETTI DI RICERCA:
A partire dal 1988 è stato responsabile di Unità di Ricerca di numerosi Progetti finanziati da Istituzioni Pubbliche o Private.
- Istituzione Finanziatrice: Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR/MURST).
- Progetti di Ricerca di Interesse Nazionale (PRIN) finanziati per gli anni 1997, 1998, 2000, 2001, 2002, 2003, 2005, 2009, 2012, 2017.
- Programma di Ricerca Nazionale sui Sistemi Neurobiologici.
- Istituzione Finanziatrice: Consiglio Nazionale delle Ricerche (CNR).
- Progetto Finalizzato "Invecchiamento",
- Progetto Strategico "Ciclo Cellulare e Apoptosi",
- Progetto Strategico "Biologia dell’ Invecchiamento",
- Progetto Strategico "Determinanti di Salute ed Invecchiamento",  
- Progetto Coordinato "Signalling in cellule infettate da HSV".
- Istituzione Finanziatrice: Ministero della Salute,
- Quinto Programma Nazionale di Ricerca sull’ AIDS.
- Istituzioni Finanziatrici: Regione Sicilia e Università Messina.
- Istituzione Finanziatrice: Istituto di Ricerca di Biologia Molecolare (IRBM) “P. Angeletti”, Pomezia.
- Istituzione Finanziatrice: Gilead Sciences S.r.l.
 
CAMPI DI RICERCA DI INTERESSE:
- Aspetti immunologici delle infezioni;
- Apoptosi e infezioni virali;
- Herpesvirus;
- Retrovirus umani;
- Terapia antivirale;
- Immunità innata;
- Timosina e citochine, meccanismi di azione e terapia combinata;
- Approcci terapeutici innovativi nelle infezioni, nei tumori e nelle malattie neurodegenerative.
 
BREVETTI:
Co-inventore di tre brevetti internazionali  e tre brevetti nazionali approvati per composti antivirali.
 
VISITE PRESSO ISTITUZIONI STRANIERE:
1996 e 1997-Visiting Scientist presso il “Department of Immunology, Medical Research Institute, University of Alexandria”, Alexandria, Egitto.
 
SOCIETA’ SCIENTIFICHE
Socio e componente del Consiglio Direttivo della Società Italiana di Microbiologia (S.I.M.); Socio e già componente del Consiglio Direttivo della Società Italiana di Microbiologia Generale e Biotecnologie Microbiche (S.I.M.G.B.M.) per il settore Virologia; Socio fondatore e componente del Comitato Consultivo della Società Italiana di Virologia-Italian Society for Virology (SIV-ISV); Socio dell’ American Society of Microbiology (ASM).I.
 
EDITORIAL ACTIVITIES:
Svolge attività di revisore per numerose  riviste scientifiche tra cui: "Cell Death and Differentiation", “Oncogene”, “Pathogens”, “Cell Death and Diseases”, "Journal of Cellular and Molecular Medicine", "International Journal of Cancer", "Trends in Pharmacological Sciences", “Journal of Medical Virology”, “Journal of Virological Methods”, “Retrovirology”, “Life Sciences”, “Current Medicinal Chemistry”.
 
PREMI:
Nel 2014 il Professor Mastino ha ricevuto il Premio “Anassilaos” per il Rilevante Contributo Scientifico nell’ Area dello Stretto di  Messina.
Nel 2018 il Professor Mastino ha ricevuto il Premio “Gilead Award Fellowship Program 2018” per Progetti di Ricerca nell’ Area HIV.
 
PUBBLICAZIONI E BIBLIOMETRIA:
Co-autore di 160 lavori pubblicati.
Citazioni: 3443; h-index: 36 (gennaio 2020).
 
Pubblicazioni degli anni recenti:
  1. Matteucci C, Marino-Merlo F, Minutolo A, Balestrieri E, Valletta E, Macchi B,Mastino A, Grelli S. Inhibition of IkBα phosphorylation potentiates regulated cell death induced by azidothymidine in HTLV-1 infected cells. Cell Death Discovery (in press).
  2. Marino-Merlo F, Papaianni E, Frezza C, Pedatella S, De Nisco M, Macchi B, Grelli S, Mastino A. NF-κB-Dependent Production of ROS and Restriction of HSV-1 Infection in U937 Monocytic Cells. Viruses 2019, 11(5), 428; https://doi.org/10.3390/v11050428 (registering DOI) - 10 May 2019. I.F. 3.761.
  3. Venuti A, Musarra-Pizzo M, Pennisi R, Tankov S, Medici MA, Mastino A, Rebane A, Sciortino MT. HSV-1\EGFP stimulates miR-146a expression in a NF-κB-dependent manner in monocytic THP-1 cells. Sci Rep. 2019 Mar 26;9(1):5157. doi: 10.1038/s41598-019-41530-5. I.F. 4.122.
  4. Usai EA, Manca I, Pettinau F, Mastino A, Pittau, B. Chemical characterization and in vitro metabolism of a novel class of delta opioid receptor agonists, analogs of SNC‐80. ChemistrySelect, 2019, 4: 2109 –2115, DOI: 10.1002/slct.201803906. I.F. 1.505.
  5. Marino-Merlo F, Macchi B, Armenia D, Bellocchi MC, Ceccherini-Silberstein F, Mastino A, Grelli S. Focus on recently developed assays for detection of resistance/sensitivity to reverse transcriptase inhibitors. Appl Microbiol Biotechnol. 2018 Dec;102(23):9925-9936. doi: 10.1007/s00253-018-9390-x. Epub 2018 Sep 29. I.F. 3.340.
  6. Matteucci C, Argaw-Denboba A, Balestrieri E, Giovinazzo A, Miele M, D'Agostini C, Pica F, Grelli S, Paci M, Mastino A, Sinibaldi Vallebona P, Garaci E, Tomino C. Deciphering cellular biological processes to clinical application: a new perspective for Tα1 treatment targeting multiple diseases. Expert Opin Biol Ther. 2018, 18(sup1):23-31. doi: 10.1080/14712598.2018.1474198. I.F. 3.974.
  7. Marino-Merlo F, Mastino A, Grelli S, Hermine O, Bazarbachi A, Macchi B. Future perspectives on drug targeting in Adult T cell Leukemia-Lymphoma Front. Microbiol. 2018.| doi: 10.3389/fmicb.2018.00925 I.F. 4.019.
  8. Marino-Merlo F, Frezza C, Papaianni E, Valletta E, Mastino A, Macchi B. Development and evaluation of a simple and effective RT-qPCR inhibitory assay for detection of the efficacy of compounds towards HIV reverse transcriptase. Appl Microbiol Biotechnol. 2017, 101:8249-8258. doi: 10.1007/s00253-017-8544-6. I.F. 3.340
  9. Marino-Merlo F, Papaianni E, Maugeri TL, Zammuto V, Spanò A, Nicolaus B, Poli A, Di Donato P, Mosca C, Mastino A, Gugliandolo C. Anti-herpes simplex virus 1 and immunomodulatory activities of a poly-γ- glutamic acid from Bacillus horneckiae strain APA of shallow vent origin. Appl Microbiol Biotechnol. 2017 101:7487–7496. DOI 10.1007/s00253-017-8472-5. I.F. 3.340
  10. Macchi B.,Balestrieri E., Frezza C.,Grelli S., Valletta E.,1 Marçais A., Marino-Merlo F.,Turpin J.,Bangham C.R., Hermine O., Mastino A.,3,9, Bazarbachi A. Quantification of HTLV-1 reverse transcriptase activity in ATL patients treated with zidovudine and interferon-a. Blood Adv. 2017 1:748-752; doi: https://doi.org/ 10.1182/ bloodadvances.2016001370.
  11. Matteucci C, Grelli S, Balestrieri E, Minutolo A, Argaw-Denboba A, Macchi B, Sinibaldi-Vallebona P, Perno CF, Mastino A, Garaci E. Thymosin alpha 1 and HIV-1: recent advances and future perspectives. Future Microbiol. 2017 Feb;12:141-155. doi: 10.2217/fmb-2016-0125. Epub 2017 Jan 20. I.F. 3.190.
  12. Marino-Merlo F, Papaianni E, Medici MA, Macchi B, Grelli S, Mosca C, Borner C, Mastino A. HSV-1-induced activation of NF-kB protects U937 monocytic cells against both virus replication and apoptosis. Cell Death and Disease. 2016. 7, e; doi:10.1038/cddis.2016.250. I.F. 5.638.
  13. Siracusano G, Venuti A, Lombardo D, Mastino A, Esclatine A, Sciortino MT. Early activation of MyD88-mediated autophagy sustains HSV-1 replication in human monocytic THP-1 cells. Sci Rep. 2016 Aug 11;6:31302. doi: 10.1038/srep31302.. I.F. 4.122.
  14. Fuggetta MP, Bordignon V, Cottarelli A, Macchi B, Frezza C, Cordiali-Fei P, Ensoli F, Ciafrè S, Marino-Merlo F, Mastino A, Ravagnan G. Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol. J Exp Clin Cancer Res. 2016 Jul 22;35(1):118. doi: 10.1186/s13046-016-0398-8. I.F. 6.217.
  15. Macchi B, Mastino A. Programmed cell death and natural killer cells in multiple sclerosis: new potential therapeutic targets? Neural Regen Res. 2016. 11: 733-734. I.F. 2.234.
  16. Frezza C, Grelli S, Federico M, Marino-Merlo F, Mastino A, Macchi B. Testing anti-HIV activity of antiretroviral agents in vitro using flow cytometry analysis of CEM-GFP cells infected with transfection-derived HIV-1 NL4-3. J Med Virol. 2016. 88:979-986. I.F. 1.988.  
  17. Macchi B, Marino-Merlo F, Nocentini U, Pisani V, Cuzzocrea S, Grelli S, Mastino A.  Role of inflammation and apoptosis in multiple sclerosis: Comparative analysis between the periphery and the central nervous system. J Neuroimmunol. 2015. 287: 80-87. I.F. 3.033.
  18. Garaci E, Pica F, Matteucci C, Gaziano R, D'Agostini C, Miele MT, Camerini R, Palamara AT, Favalli C, Mastino A, Serafino A, Sinibaldi Vallebona P. Historical review on thymosin α1 in oncology: preclinical and clinical experiences. Expert Opin Biol Ther. 2015. 15, supp 1: 31-39. I.F. 3.974.
  19. Matteucci C, Minutolo A, Pollicita M, Balestrieri E, Grelli S, D'Ettorre G, Vullo V, Bucci I, Luchini A, Aquaro S, Sinibaldi-Vallebona P, Macchi B, Perno CF, Mastino A, Garaci E. Thymosin α 1 potentiates the release by CD8+ cells of soluble factors able to inhibit HIV-1 and human T lymphotropic virus 1 infection in vitro. Expert Opin Biol Ther. 2015. 15, supp 1: 83-100. I.F. 3.974.
  20. Papaianni E, El Maadidi S, Schejtman A, Neumann S, Maurer U, Marino-Merlo F, Mastino A, Borner C. Phylogenetically distant viruses use the same BH3-only protein Puma to trigger Bax/Bak-dependent apoptosis of infected mouse and human cells. PLoS ONE 10(6): e0126645. doi:10.1371/journal. I.F. 2.766.
  21. Macchi B, Romeo G, Chiacchio U, Frezza C, Giofre` SV, Marino-Merlo F,  Mastino A. Phosphonated nucleoside analogues as antiviral agents. Top Med Chem. 2015. 15: 53–92.
  22. Matteucci C, Minutolo A, Marino-Merlo F, Grelli S, Frezza C, Mastino A, Macchi B. Characterization of the enhanced apoptotic response to azidothymidine by pharmacological inhibition of NF-kB. Life Sci. 2015. 127: 90-97  I.F. 3.234.
  23. Macchi B, Paola DR, Marino-Merlo F, Felice MR, Cuzzocrea S, Mastino A. Inflammatory and Cell Death Pathways in Brain and Peripheral Blood in Parkinson's disease. CNS Neurol Disord Drug Targets. 2015. 14:313-324  I.F. 2.084.
  24. Macchi B, Marino-Merlo F, Frezza C, Cuzzocrea S, Mastino A. Inflammation and programmed cell death in Alzheimer’s disease: comparison of the central nervous system and the peripheral blood. Mol Neurobiol. 2014.  50:463-472. I.F. 5.076.  
  25. Nucci A, Marino-Merlo F, De Nisco M, Pedatella S, Rossi F, Jacob C, Caputo R, Mastino A. Se-(2-aminoalkyl)selenocysteines as biochemical redox agents. A tool to contrast cell injury induced by aflatoxin B1 in HepG2 cells. Amino Acids. 2014. 46:459-70. I.F. 2.906.  
  26. Frezza C, Balestrieri E, Marino-Merlo F, Mastino A, Macchi B.  A novel, cell-free PCR-based assay for evaluating the inhibitory activity of antiretroviral compounds against HIV reverse transcriptase.  J. Med. Virol. 2014. 86:1–7.  I.F. 1.988.
  27. Sciortino MT, Parisi T, Siracusano G, Mastino A, Taddeo B, Roizman B. The virion host shut-off RNase plays a key role in blocking the activation of Protein kinase R in cells infected with Herpes Simplex Virus 1. J Virol. 2013.  87:3271 -3276. I.F. 4.368.
  28. Minutolo A, Grelli S, Marino-Merlo F, Cordero FM, Brandi A, Macchi B, Mastino A. D(-) lentiginosine-induced apoptosis involves the intrinsic pathway and is p53-independent. Cell Death Dis. 2012 Jul 26;3:e358. doi: 10.1038/cddis.2012.97. I.F. 5.638.
  29. Bonaccorsi  P, Marino-Merlo F, Barattucci A, Battaglia G, Papaianni P, Papalia T, Aversa MC, Mastino A. Synthesis and biological evaluation of a new class of glycoconjugated disulfides that exhibit potential anticancer properties. Bioorg Med Chem. 2012. 20:3186-3195.  I.F. 2.881.
  30. Romeo R, Giofrè SV, Macchi B, Balestrieri E, Mastino A, Merino P, Carnovale C, Romeo G, Chiacchio U. Truncated reverse isoxazolidinyl nucleosides: a new class of allosteric HIV-1 reverse transcriptase inhibitors. ChemMedChem. 2012, 7: 565-569. I.F. 3.009.
  31. Cordero FM, Bonanno P, Khairnar BB, Cardona F, Brandi A, Macchi B, Minutolo A, Grelli S, Mastino A.   (_)-(1R,2R,7S,8aR)-1,2,7-Trihydroxyindolizidine ((_)-7S-OHLentiginosine): synthesis and proapoptotic activity. ChemPlusChem.  2012, 77: 224-233. I.F. 3.205.
  32. Ascolani A, Balestrieri E, Minutolo A, Mosti S, Spalletta G, Bramanti P, Mastino A, Caltagirone C, Macchi B. Dysregulated NF-κB pathway in peripheral mononuclear cells of Alzheimer's disease patients. Curr Alzheimer Res. 2012. 19: 128-137.  I.F. 3.289.
  33. Rufini A, Agostini M, Grespi F, Tomasini R, Sayan BS, Niklison-Chirou MV, Conforti F, Velletri T, Mastino A, Mak TW, Melino G, Knight RA.  p73 in Cancer. Genes & Cancer. 2011 2:491-502
  34. Macchi B, Balestrieri E, Ascolani A, Hilburn S, Martin F, Mastino A, Taylor GP. Susceptibility of primary HTLV-1 isolates from patients with HTLV-1-associated myelopathy to reverse transcriptase inhibitors. Viruses 2011. 3: 469-483. I.F. 3.761.
  35. Balestrieri E, Pizzimenti F, Ferlazzo A, Giofrè SV, Iannazzo D, Piperno A, Romeo R, Chiacchio MA, Mastino A, Macchi B. Antiviral activity of seed extract from Citrus bergamia towards human retroviruses. Bioorg Med Chem. 2011. 19:2084-2089. I.F. 2.881.
  36. Matteucci C, Minutolo A, Balestrieri E, Marino-Merlo F, Bramanti P, Garaci E, Macchi B, Mastino A. Inhibition of NF-kB activation sensitizes U937 cells to 3’-azido-3’-deoxythymidine (AZT) induced apoptosis. Cell Death and Disease. 2010. 1, e81; doi:10.1038/cddis.2010.58. I.F. 5.638.
  37. Matteucci C, Minutolo A, Sinibaldi-Vallebona P, Palamara AT, Rasi G, Mastino A, Garaci E. Transcription profile of human lymphocytes following in vitro treatment with thymosin alpha. Ann N Y Acad Sci. 2010. 1194:6-19. I.F. 4.277. 
  38. Macchi B, Minutolo A, Grelli S, Cardona F, Cordero FM, Mastino A, Brandi A.  The novel proapoptotic activity of non-natural enantiomer of Lentiginosine Glycobiology. 2010. 20:500-6. I.F. 3.664.
  39. Chiacchio U, Borrello L, Crispino L, Rescifina A, Merino P, Macchi B, Balestrieri E, Mastino A, Piperno A, Romeo G. Stereoselective Synthesis and Biological Evaluations of Novel 3'-Deoxy-4'-azaribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication. J Med Chem. 2009. 59: 4054-57.  I.F 6.253.
  40. Aversa MC, Barattucci A, Bonaccorsi P, Marino-Merlo F, Mastino A, Sciortino MT. Synthesis and biological testing of thioalkane- and thioarene-spaced bis-beta-D-glucopyranosides. Bioorg Med Chem. 2009. 17:1456-63. I.F. 2.881.
  41. Serafino A, Balestrieri E, Pierimarchi P, Matteucci C, Moroni G, Oricchio E, Rasi G, Mastino A, Spadafora C, Garaci E, Sinibaldi Vallebona P. The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation. Exp. Cell. Res. 2009. 315:849-62. I.F. 3.309.
  42. Matteucci C, Minutolo A, Balestrieri E, Ascolani A, Grelli S, Macchi B, Mastino A. Effector caspase activation, in the absence of a conspicuous apoptosis induction, in mononuclear cells treated with azidothymidine. Pharmacol Res. 2009. 59:125-33. I.F. 4.897.
  43. Sciortino M.T., Medici M.A., Marino-Merlo F., Zaccaria D., Venuti A., Giuffrè-Cuculletto M., Perri D.,  Grelli S., Mastino A. Signaling activity by herpes simplex virus: molecular mechanisms and biotechnological implications. In: New Strides in Biotechnology. Anastasi GP, Saija A, Gonzalez Roncero MI, Torres Aguilar M, Newsome HH, Skunda R, Eds. 2008. pp.229-241.
  44. Iannazzo D., Piperno A., Romeo G., Romeo R., Chiacchio U., Rescifina A., Balestrieri E., Macchi B., Mastino A., Cortese R. 3-Amino-2(5H)furanoses as inhibitors of subgenomic hepatitis C virus RNA replication. Bioorg Med Chem. 16:9610-9615 (2008) I.F. 2.881.
  45. Sciortino M.T., Medici M.A., Marino-Merlo F., Zaccaria D., Giuffrè-Cuculletto M., Venuti A., Grelli S., Bramanti P., Mastino A. Involvement of gD/HVEM interaction in  NF-kB-dependent inhibition of apoptosis by  by HSV-1 gD. Biochem Pharmacol., 76: 1522-1532 (2008) I.F. 4.235.
  46. Sciortino M.T., Medici M.A., Marino-Merlo F., Zaccaria D., Giuffrè-Cuculletto M., Venuti A., Grelli S., Mastino A. Involvement of  HVEM receptor in activation of nuclear factor kB by HSV-1 glycoprotein D. Cell.  Microbiol., 10: 2297-2311 (2008) I.F.  4.410.
  47. Balestrieri E, Ascolani A, Igarashi Y, Oki T, Mastino A, Balzarini J, Macchi B. Inhibition of cell-to-cell transmission of human T-cell Lymphotropic virus type 1 in vitro by carbohydrate-binding agents. Antimicrob Agents Chemother. 52: 2771-2779 (2008) I.F. 4.256.
  48. Mastino A., Basu S., Brunner T., Ricci J.E., Diederich M. Long live the cell death! Cell Death Differ.,  15: 1330-1332 (2008) I.F. 8.000
  49. Balestrieri E., Matteucci C., Ascolani A., Piperno A., Romeo R., Romeo G., Chiacchio U., Mastino A., Macchi B. Effect of phosphonated carbocyclic 2'-oxa-3'-aza-nucleoside on HTLV-1 infection in vitro. Antimicrob Agents Chemother. 52: 54-64 (2008) I.F. 4.256.
 
 

    Curriculum

     
     
     
     
    Antonio Mastino, Ph.D.
     
    CONTACT DETAILS:
    Department of Chemical, Biological, Pharmaceutical
    and Environmental Sciences,
    University of Messina,
    Via F. Stagno d'Alcontres, 31
    98166 - Messina – ITALY
    tel. +39 3388658161 (mobile)
    e-mail: antonio.mastino@unime.it
     
     
    SHORT BIOGRAPHY
     
    Professor Antonio Mastino received his MSc Degree in Biological Science and his DSc Degree in Microbiology from the University of Rome Sapienza, in Rome. He then worked as Researcher at the University of Rome “Tor Vergata” in Rome. Subsequently, in 1995, he was appointed as Full Professor of General Microbiology and moved to the University of Messina, in Messina, where is still currently in the staff. At the University of Messina, professor Mastino also served, for several years, as Head of the Departments of  Microbiological, Genetic and Molecular Sciences, first, and of Life Sciences “M. Malpighi”, successively, and as delegate of the President of  the University for Research Resource Management.
    He currently also serves as the President of the Research Area of Rome Tor Vergata of The National Research Council (CNR), Rome, since 2013, and served as the Director of the Institute of Translational Pharmacology of CNR, Rome.
     
    Responsabilities of funded Research Projects:
    Starting from 1988 served as head of research unit for a number of awarded grants from public and private institutions.
    - Funding Institution: The Italian Ministry for Education, University and Research (MIUR/MURST).
    - Research Projects of National Interest (PRIN) funded for years 1997, 1998, 2000, 2001, 2002, 2003, 2005, 2009, 2012, 2017.
    - National Research Program on Neurobiological Systems.
    - Funding Institution: The Italian National Research Council (CNR).
    - Finalized Project "Aging",
    - Strategic Project "Cell Cycle and Apoptosis",
    - Strategic Project "Biology of Aging",
    - Strategic Project "Health determinant and Aging",  
    - Coordinated Project "Signalling in HSV infected cells".
    - Funding Institution: The Italian Ministry of Health,
    - The fifth National Research Program on AIDS.
    - Funding Institutions: Regione Sicilia and the University of Messina.
    - Funding Institition: The Research Institute for Molecular Biology (IRBM) “P. Angeletti”, Pomezia.
    - Funding Institution: Gilead Sciences S.r.l.
     
    FIELDS OF RESEARCH INTEREST:
    Immunological aspects of infections;
    apoptosis and viral infections;
    herpesviruses;
    human retroviruses;
    antiviral therapy;
    innate immunity;
    thymosins and cytokines, mechanisms of action and combination activity;
    innovative therapeutic approaches to infections, cancer and neurodegenerative diseases.
     
    PATENTS:
    Co-inventor of three approved international patents and three national patents for antiviral compounds.
     
    VISITS TO FOREIGN INSTITUTIONS:
    1996 and 1997-Visiting scientist at the Department of Immunology, Medical Research Institute, University of Alexandria, Alexandria, Egypt.
     
    SCIENTIFIC SOCIETIES:
    Founding Member and member of the Board of Consultants of The Italian Society for Virology (SIV-ISV); member and member of the Board of The Italian Society for Microbiology; member and past member of the Board for Virology of the Italian Society of General Microbiology and Microbial Biotechnology”;  Member of ASM.
     
    EDITORIAL ACTIVITIES:
    Serves as reviewer for scientific journals, including: "Cell Death and Differentiation", “Oncogene”, “Pathogens”, “Cell Death and Diseases”, "Journal of Cellular and Molecular Medicine", "International Journal of Cancer", "Trends in Pharmacological Sciences", “Journal of Medical Virology”, “Journal of Virological Methods”, “Retrovirology”, “Life Sciences”, “Current Medicinal Chemistry”.
     
    AWARDS:
    In 2014 Professor Mastino received the “Anassilaos Award” for Distinguished Scientific Contributions  in the Area of the Strait of Messina.
    In 2018 Professor Mastino received the “Gilead Award Fellowship Program 2018” for research projects in the Area of HIV.
     
    ACADEMIC QUALIFICATION: Degree in Biological Sciences, University of Rome. Specialization in Microbiology, Faculty of Medicine, University of Rome.
     
    PUBLICATIONS AND BIBLIOMETRICS:
    Co-author of 160 printed papers.
    Citations: 3443; h-index: 36 (January 2020).
     
    List of publications in the recent years:
    1. Matteucci C, Marino-Merlo F, Minutolo A, Balestrieri E, Valletta E, Macchi B,Mastino A, Grelli S. Inhibition of IkBα phosphorylation potentiates regulated cell death induced by azidothymidine in HTLV-1 infected cells. Cell Death Discovery (in press).
    2. Marino-Merlo F, Papaianni E, Frezza C, Pedatella S, De Nisco M, Macchi B, Grelli S, Mastino A. NF-κB-Dependent Production of ROS and Restriction of HSV-1 Infection in U937 Monocytic Cells. Viruses 2019, 11(5), 428; https://doi.org/10.3390/v11050428 (registering DOI) - 10 May 2019. I.F. 3.761.
    3. Venuti A, Musarra-Pizzo M, Pennisi R, Tankov S, Medici MA, Mastino A, Rebane A, Sciortino MT. HSV-1\EGFP stimulates miR-146a expression in a NF-κB-dependent manner in monocytic THP-1 cells. Sci Rep. 2019 Mar 26;9(1):5157. doi: 10.1038/s41598-019-41530-5. I.F. 4.122.
    4. Usai EA, Manca I, Pettinau F, Mastino A, Pittau, B. Chemical characterization and in vitro metabolism of a novel class of delta opioid receptor agonists, analogs of SNC‐80. ChemistrySelect, 2019, 4: 2109 –2115, DOI: 10.1002/slct.201803906. I.F. 1.505.
    5. Marino-Merlo F, Macchi B, Armenia D, Bellocchi MC, Ceccherini-Silberstein F, Mastino A, Grelli S. Focus on recently developed assays for detection of resistance/sensitivity to reverse transcriptase inhibitors. Appl Microbiol Biotechnol. 2018 Dec;102(23):9925-9936. doi: 10.1007/s00253-018-9390-x. Epub 2018 Sep 29. I.F. 3.340.
    6. Matteucci C, Argaw-Denboba A, Balestrieri E, Giovinazzo A, Miele M, D'Agostini C, Pica F, Grelli S, Paci M, Mastino A, Sinibaldi Vallebona P, Garaci E, Tomino C. Deciphering cellular biological processes to clinical application: a new perspective for Tα1 treatment targeting multiple diseases. Expert Opin Biol Ther. 2018, 18(sup1):23-31. doi: 10.1080/14712598.2018.1474198. I.F. 3.974.
    7. Marino-Merlo F, Mastino A, Grelli S, Hermine O, Bazarbachi A, Macchi B. Future perspectives on drug targeting in Adult T cell Leukemia-Lymphoma Front. Microbiol. 2018.| doi: 10.3389/fmicb.2018.00925 I.F. 4.019.
    8. Marino-Merlo F, Frezza C, Papaianni E, Valletta E, Mastino A, Macchi B. Development and evaluation of a simple and effective RT-qPCR inhibitory assay for detection of the efficacy of compounds towards HIV reverse transcriptase. Appl Microbiol Biotechnol. 2017, 101:8249-8258. doi: 10.1007/s00253-017-8544-6. I.F. 3.340
    9. Marino-Merlo F, Papaianni E, Maugeri TL, Zammuto V, Spanò A, Nicolaus B, Poli A, Di Donato P, Mosca C, Mastino A, Gugliandolo C. Anti-herpes simplex virus 1 and immunomodulatory activities of a poly-γ- glutamic acid from Bacillus horneckiae strain APA of shallow vent origin. Appl Microbiol Biotechnol. 2017 101:7487–7496. DOI 10.1007/s00253-017-8472-5. I.F. 3.340
    10. Macchi B.,Balestrieri E., Frezza C.,Grelli S., Valletta E.,1 Marçais A., Marino-Merlo F.,Turpin J.,Bangham C.R., Hermine O., Mastino A.,3,9, Bazarbachi A. Quantification of HTLV-1 reverse transcriptase activity in ATL patients treated with zidovudine and interferon-a. Blood Adv. 2017 1:748-752; doi: https://doi.org/ 10.1182/ bloodadvances.2016001370.
    11. Matteucci C, Grelli S, Balestrieri E, Minutolo A, Argaw-Denboba A, Macchi B, Sinibaldi-Vallebona P, Perno CF, Mastino A, Garaci E. Thymosin alpha 1 and HIV-1: recent advances and future perspectives. Future Microbiol. 2017 Feb;12:141-155. doi: 10.2217/fmb-2016-0125. Epub 2017 Jan 20. I.F. 3.190.
    12. Marino-Merlo F, Papaianni E, Medici MA, Macchi B, Grelli S, Mosca C, Borner C, Mastino A. HSV-1-induced activation of NF-kB protects U937 monocytic cells against both virus replication and apoptosis. Cell Death and Disease. 2016. 7, e; doi:10.1038/cddis.2016.250. I.F. 5.638.
    13. Siracusano G, Venuti A, Lombardo D, Mastino A, Esclatine A, Sciortino MT. Early activation of MyD88-mediated autophagy sustains HSV-1 replication in human monocytic THP-1 cells. Sci Rep. 2016 Aug 11;6:31302. doi: 10.1038/srep31302.. I.F. 4.122.
    14. Fuggetta MP, Bordignon V, Cottarelli A, Macchi B, Frezza C, Cordiali-Fei P, Ensoli F, Ciafrè S, Marino-Merlo F, Mastino A, Ravagnan G. Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol. J Exp Clin Cancer Res. 2016 Jul 22;35(1):118. doi: 10.1186/s13046-016-0398-8. I.F. 6.217.
    15. Macchi B, Mastino A. Programmed cell death and natural killer cells in multiple sclerosis: new potential therapeutic targets? Neural Regen Res. 2016. 11: 733-734. I.F. 2.234.
    16. Frezza C, Grelli S, Federico M, Marino-Merlo F, Mastino A, Macchi B. Testing anti-HIV activity of antiretroviral agents in vitro using flow cytometry analysis of CEM-GFP cells infected with transfection-derived HIV-1 NL4-3. J Med Virol. 2016. 88:979-986. I.F. 1.988.  
    17. Macchi B, Marino-Merlo F, Nocentini U, Pisani V, Cuzzocrea S, Grelli S, Mastino A.  Role of inflammation and apoptosis in multiple sclerosis: Comparative analysis between the periphery and the central nervous system. J Neuroimmunol. 2015. 287: 80-87. I.F. 3.033.
    18. Garaci E, Pica F, Matteucci C, Gaziano R, D'Agostini C, Miele MT, Camerini R, Palamara AT, Favalli C, Mastino A, Serafino A, Sinibaldi Vallebona P. Historical review on thymosin α1 in oncology: preclinical and clinical experiences. Expert Opin Biol Ther. 2015. 15, supp 1: 31-39. I.F. 3.974.
    19. Matteucci C, Minutolo A, Pollicita M, Balestrieri E, Grelli S, D'Ettorre G, Vullo V, Bucci I, Luchini A, Aquaro S, Sinibaldi-Vallebona P, Macchi B, Perno CF, Mastino A, Garaci E. Thymosin α 1 potentiates the release by CD8+ cells of soluble factors able to inhibit HIV-1 and human T lymphotropic virus 1 infection in vitro. Expert Opin Biol Ther. 2015. 15, supp 1: 83-100. I.F. 3.974.
    20. Papaianni E, El Maadidi S, Schejtman A, Neumann S, Maurer U, Marino-Merlo F, Mastino A, Borner C. Phylogenetically distant viruses use the same BH3-only protein Puma to trigger Bax/Bak-dependent apoptosis of infected mouse and human cells. PLoS ONE 10(6): e0126645. doi:10.1371/journal. I.F. 2.766.
    21. Macchi B, Romeo G, Chiacchio U, Frezza C, Giofre` SV, Marino-Merlo F,  Mastino A. Phosphonated nucleoside analogues as antiviral agents. Top Med Chem. 2015. 15: 53–92.
    22. Matteucci C, Minutolo A, Marino-Merlo F, Grelli S, Frezza C, Mastino A, Macchi B. Characterization of the enhanced apoptotic response to azidothymidine by pharmacological inhibition of NF-kB. Life Sci. 2015. 127: 90-97  I.F. 3.234.
    23. Macchi B, Paola DR, Marino-Merlo F, Felice MR, Cuzzocrea S, Mastino A. Inflammatory and Cell Death Pathways in Brain and Peripheral Blood in Parkinson's disease. CNS Neurol Disord Drug Targets. 2015. 14:313-324  I.F. 2.084.
    24. Macchi B, Marino-Merlo F, Frezza C, Cuzzocrea S, Mastino A. Inflammation and programmed cell death in Alzheimer’s disease: comparison of the central nervous system and the peripheral blood. Mol Neurobiol. 2014.  50:463-472. I.F. 5.076.  
    25. Nucci A, Marino-Merlo F, De Nisco M, Pedatella S, Rossi F, Jacob C, Caputo R, Mastino A. Se-(2-aminoalkyl)selenocysteines as biochemical redox agents. A tool to contrast cell injury induced by aflatoxin B1 in HepG2 cells. Amino Acids. 2014. 46:459-70. I.F. 2.906.  
    26. Frezza C, Balestrieri E, Marino-Merlo F, Mastino A, Macchi B.  A novel, cell-free PCR-based assay for evaluating the inhibitory activity of antiretroviral compounds against HIV reverse transcriptase.  J. Med. Virol. 2014. 86:1–7.  I.F. 1.988.
    27. Sciortino MT, Parisi T, Siracusano G, Mastino A, Taddeo B, Roizman B. The virion host shut-off RNase plays a key role in blocking the activation of Protein kinase R in cells infected with Herpes Simplex Virus 1. J Virol. 2013.  87:3271 -3276. I.F. 4.368.
    28. Minutolo A, Grelli S, Marino-Merlo F, Cordero FM, Brandi A, Macchi B, Mastino A. D(-) lentiginosine-induced apoptosis involves the intrinsic pathway and is p53-independent. Cell Death Dis. 2012 Jul 26;3:e358. doi: 10.1038/cddis.2012.97. I.F. 5.638.
    29. Bonaccorsi  P, Marino-Merlo F, Barattucci A, Battaglia G, Papaianni P, Papalia T, Aversa MC, Mastino A. Synthesis and biological evaluation of a new class of glycoconjugated disulfides that exhibit potential anticancer properties. Bioorg Med Chem. 2012. 20:3186-3195.  I.F. 2.881.
    30. Romeo R, Giofrè SV, Macchi B, Balestrieri E, Mastino A, Merino P, Carnovale C, Romeo G, Chiacchio U. Truncated reverse isoxazolidinyl nucleosides: a new class of allosteric HIV-1 reverse transcriptase inhibitors. ChemMedChem. 2012, 7: 565-569. I.F. 3.009.
    31. Cordero FM, Bonanno P, Khairnar BB, Cardona F, Brandi A, Macchi B, Minutolo A, Grelli S, Mastino A.   (_)-(1R,2R,7S,8aR)-1,2,7-Trihydroxyindolizidine ((_)-7S-OHLentiginosine): synthesis and proapoptotic activity. ChemPlusChem.  2012, 77: 224-233. I.F. 3.205.
    32. Ascolani A, Balestrieri E, Minutolo A, Mosti S, Spalletta G, Bramanti P, Mastino A, Caltagirone C, Macchi B. Dysregulated NF-κB pathway in peripheral mononuclear cells of Alzheimer's disease patients. Curr Alzheimer Res. 2012. 19: 128-137.  I.F. 3.289.
    33. Rufini A, Agostini M, Grespi F, Tomasini R, Sayan BS, Niklison-Chirou MV, Conforti F, Velletri T, Mastino A, Mak TW, Melino G, Knight RA.  p73 in Cancer. Genes & Cancer. 2011 2:491-502
    34. Macchi B, Balestrieri E, Ascolani A, Hilburn S, Martin F, Mastino A, Taylor GP. Susceptibility of primary HTLV-1 isolates from patients with HTLV-1-associated myelopathy to reverse transcriptase inhibitors. Viruses 2011. 3: 469-483. I.F. 3.761.
    35. Balestrieri E, Pizzimenti F, Ferlazzo A, Giofrè SV, Iannazzo D, Piperno A, Romeo R, Chiacchio MA, Mastino A, Macchi B. Antiviral activity of seed extract from Citrus bergamia towards human retroviruses. Bioorg Med Chem. 2011. 19:2084-2089. I.F. 2.881.
    36. Matteucci C, Minutolo A, Balestrieri E, Marino-Merlo F, Bramanti P, Garaci E, Macchi B, Mastino A. Inhibition of NF-kB activation sensitizes U937 cells to 3’-azido-3’-deoxythymidine (AZT) induced apoptosis. Cell Death and Disease. 2010. 1, e81; doi:10.1038/cddis.2010.58. I.F. 5.638.
    37. Matteucci C, Minutolo A, Sinibaldi-Vallebona P, Palamara AT, Rasi G, Mastino A, Garaci E. Transcription profile of human lymphocytes following in vitro treatment with thymosin alpha. Ann N Y Acad Sci. 2010. 1194:6-19. I.F. 4.277. 
    38. Macchi B, Minutolo A, Grelli S, Cardona F, Cordero FM, Mastino A, Brandi A.  The novel proapoptotic activity of non-natural enantiomer of Lentiginosine Glycobiology. 2010. 20:500-6. I.F. 3.664.
    39. Chiacchio U, Borrello L, Crispino L, Rescifina A, Merino P, Macchi B, Balestrieri E, Mastino A, Piperno A, Romeo G. Stereoselective Synthesis and Biological Evaluations of Novel 3'-Deoxy-4'-azaribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication. J Med Chem. 2009. 59: 4054-57.  I.F 6.253.
    40. Aversa MC, Barattucci A, Bonaccorsi P, Marino-Merlo F, Mastino A, Sciortino MT. Synthesis and biological testing of thioalkane- and thioarene-spaced bis-beta-D-glucopyranosides. Bioorg Med Chem. 2009. 17:1456-63. I.F. 2.881.
    41. Serafino A, Balestrieri E, Pierimarchi P, Matteucci C, Moroni G, Oricchio E, Rasi G, Mastino A, Spadafora C, Garaci E, Sinibaldi Vallebona P. The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation. Exp. Cell. Res. 2009. 315:849-62. I.F. 3.309.
    42. Matteucci C, Minutolo A, Balestrieri E, Ascolani A, Grelli S, Macchi B, Mastino A. Effector caspase activation, in the absence of a conspicuous apoptosis induction, in mononuclear cells treated with azidothymidine. Pharmacol Res. 2009. 59:125-33. I.F. 4.897.
    43. Sciortino M.T., Medici M.A., Marino-Merlo F., Zaccaria D., Venuti A., Giuffrè-Cuculletto M., Perri D.,  Grelli S., Mastino A. Signaling activity by herpes simplex virus: molecular mechanisms and biotechnological implications. In: New Strides in Biotechnology. Anastasi GP, Saija A, Gonzalez Roncero MI, Torres Aguilar M, Newsome HH, Skunda R, Eds. 2008. pp.229-241.
    44. Iannazzo D., Piperno A., Romeo G., Romeo R., Chiacchio U., Rescifina A., Balestrieri E., Macchi B., Mastino A., Cortese R. 3-Amino-2(5H)furanoses as inhibitors of subgenomic hepatitis C virus RNA replication. Bioorg Med Chem. 16:9610-9615 (2008) I.F. 2.881.
    45. Sciortino M.T., Medici M.A., Marino-Merlo F., Zaccaria D., Giuffrè-Cuculletto M., Venuti A., Grelli S., Bramanti P., Mastino A. Involvement of gD/HVEM interaction in  NF-kB-dependent inhibition of apoptosis by  by HSV-1 gD. Biochem Pharmacol., 76: 1522-1532 (2008) I.F. 4.235.
    46. Sciortino M.T., Medici M.A., Marino-Merlo F., Zaccaria D., Giuffrè-Cuculletto M., Venuti A., Grelli S., Mastino A. Involvement of  HVEM receptor in activation of nuclear factor kB by HSV-1 glycoprotein D. Cell.  Microbiol., 10: 2297-2311 (2008) I.F.  4.410.
    47. Balestrieri E, Ascolani A, Igarashi Y, Oki T, Mastino A, Balzarini J, Macchi B. Inhibition of cell-to-cell transmission of human T-cell Lymphotropic virus type 1 in vitro by carbohydrate-binding agents. Antimicrob Agents Chemother. 52: 2771-2779 (2008) I.F. 4.256.
    48. Mastino A., Basu S., Brunner T., Ricci J.E., Diederich M. Long live the cell death! Cell Death Differ.,  15: 1330-1332 (2008) I.F. 8.000
    49. Balestrieri E., Matteucci C., Ascolani A., Piperno A., Romeo R., Romeo G., Chiacchio U., Mastino A., Macchi B. Effect of phosphonated carbocyclic 2'-oxa-3'-aza-nucleoside on HTLV-1 infection in vitro. Antimicrob Agents Chemother. 52: 54-64 (2008) I.F. 4.256.
     
     

I dati visualizzati nella sezione sono recuperati dalla Procedura Gestione Carriere e Stipendi del Personale (CSA), dalla Procedura Gestione Studenti (ESSE3), da Iris e dal Sito Docenti MIUR.

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